Study of the Formulation Parameters Affecting the Preparation of Microencapsulated Ion-Exchange Resins Containing Venlafaxine Hydrochloride

Venlafaxine is a novel, non-tricyclic antidepressant. Venlafaxine imparts its antidepressant effects by inhibiting the neuronal uptake of norepinephrine, serotonin and to a lesser extent, dopamine1. It lacks monoamine oxidase activity and, more importantly, lacks the adverse effect profile of tricyclic antidepressants. Now, there has been the sustained-release preparation of this drug coming into the market, but there are no marketed products of microencapsulated ion-exchange resins containing venlafaxine hydrochloride.